相关实验视频
Updated: May 5, 2026

12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 27, 2013
33.7K
IL-21启动一种替代途径来诱导促炎性T(H) 17细胞
Thomas Korn1, Estelle Bettelli1, Wenda Gao2
1Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nature
|June 22, 2007
概括
干白素-6 (IL-6) 对于T辅助细胞17 (T(H) 17的分化至关重要. 在缺乏IL-6的小鼠中,调节性T (Treg) 细胞占主导地位,但IL-21可以诱导T (H) 17细胞,揭示出替代途径.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 纯粹的T细胞分化为专门的效应子集,包括T辅助17 (T(H) 17细胞,在自身免疫和炎症中发挥作用.
- 转化生长因子-β (TGF-β) 和互白素-6 (IL-6) 一起诱导T(H) 17细胞的分化,IL-6关键地决定了T(H) 17和调节性T (Treg) 细胞之间的平衡.
研究的目的:
- 在体内研究IL-6在T(H) 17和Treg细胞分化中的作用.
- 为了确定T(H) 17细胞生成的替代途径.
主要方法:
- 利用缺少IL-6 (Il6-/-) 的小鼠研究T细胞分化.
- 研究了Treg细胞枯竭对Il6-/-小鼠T(H) 17细胞种群的影响.
- 研究了IL-21在天真Il6-/- T细胞中的T(H) 17细胞诱导中的作用.
- 分析了缺乏IL-21受体的T细胞.
主要成果:
- 缺少IL-6的小鼠表现出缺乏T(H) 17反应和Treg细胞的扩张.
- 在IL-6缺乏的小鼠中,Treg细胞的枯竭导致了T(H) 17细胞的重新出现,表明了另一个体内生成途径.
- 发现介质素-21 (IL-21) 与TGF-β合作,在原始的IL-6缺乏T细胞中诱导T(H) 17细胞.
- 缺少IL-21受体的T细胞在T(H) 17细胞生成中表现出缺陷.
结论:
- IL-6在T(H) 17细胞分化中发挥着关键作用,与Treg细胞发育平衡.
- 对于T(H) 17细胞的产生,存在一种依赖IL-21的途径,特别是在没有IL-6的情况下.
- 这些发现阐明了控制T辅助细胞子集分化的复杂调控机制.
相关概念视频
Cell-mediated Immune Responses
64.7K
Overview
64.7K
NF-κB-dependent Signaling Pathway
7.6K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.6K
Cells of the Adaptive Immune Response
6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K
T Cell Activation and Clonal Selection
13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K
T Cell Types and Functions
3.2K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K
B Cell Activation and Differentiation
14.4K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
14.4K

