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罗西格利塔试验的数据和安全监测

Elizabeth G Nabel, Susan B Shurin, Denise G Simons-Morton

    Lancet (London, England)
    |June 26, 2007
    PubMed
    概括

    No abstract available in PubMed .

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    Toxicity Testing in Animals01:23

    Toxicity Testing in Animals

    Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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