神经母细胞瘤是一种神经母细胞瘤
John M Maris1, Michael D Hogarty, Rochelle Bagatell
1Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA. maris@chop.edu
Lancet (London, England)
|June 26, 2007
概括
神经母细胞瘤是一种复杂的儿科癌症,表现出显著的异质性. 了解其生物学和分子病原体是开发改进,风险分层治疗和新疗法以提高生存率的关键.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症生物学 癌症生物学
- 翻译研究是翻译研究.
背景情况:
- 神经母细胞瘤表现出显著的临床异质性,影响基于年龄,疾病程度和瘤生物学的治愈率.
- 大约50%的神经母细胞瘤病例是高风险的,尽管进行了密集治疗,但存活率很低 (<40%).
- 瘤的行为范围从自发回归到无情的进展.
研究的目的:
- 审查神经母细胞瘤生物学和分子病变发生的最新进展.
- 概述一个统一的国际神经母细胞瘤风险组 (INRG) 分类系统的发展.
- 总结基于风险的治疗策略,并讨论新的治疗方法.
主要方法:
- 关于神经母细胞瘤生物学和临床管理的当前文献的综述.
- 关于拟议的国际神经母细胞瘤风险组 (INRG) 分类的讨论.
- 对新出现的分子标和治疗策略的分析.
主要成果:
- 最近分子病原学的发现可以转化为临床实践.
- 计划开发一个统一的INRG分类系统.
- 新型治疗点为更有效,更少毒性治疗提供了潜力.
结论:
- 了解神经母细胞瘤的复杂生物学是改善结果的关键.
- 基于风险的分类和向治疗对于高风险患者至关重要.
- 分子致病学的进步为改善治疗策略,降低毒性铺平了道路.
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