在外围动脉疾病中补充L-氨酸:没有益处和可能的危害
Andrew M Wilson1, Randall Harada, Nandini Nair
1Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, Calif 94305, USA.
Circulation
|June 27, 2007
概括
长期服用L-氨酸补充剂并没有改善周围动脉疾病 (PAD) 患者的氧化合成或血管功能. 该研究发现,与安慰剂相比,对音距离没有益处和潜在的有害影响.
科学领域:
- 心血管研究研究心血管研究
- 血管生物学 血管生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氨酸是氧化的前体,是一种血管扩展剂.
- 短期的L-氨酸补充剂在周围动脉疾病 (PAD) 中显示出有前途.
- 在PAD中对血管反应和功能能力的长期影响尚不清楚.
研究的目的:
- 评估L-氨酸对PAD患者血管反应能力和功能能力的长期影响.
- 评估L-氨酸补充剂是否可以改善PAD中氧化的可用性.
主要方法:
- 无疼痛研究是一项为期6个月的随机临床试验.
- 133名因PAD间歇性听症的受试者接受了口服L-氨酸 (3g/d) 或安慰剂.
- 主要终点:通过跑步机测试改变绝对音距离.
主要成果:
- 氨酸增加了血L-氨酸水平,但没有改善氧化可用性标志物.
- 绝对音距离在两组都得到改善,但在L-氨酸组 (28.3%对11.5%) 的改善较小.
- 在L-氨酸组中,对功能能力的安慰剂效应减弱.
结论:
- 长期使用L-氨酸并不增强PAD中氧化的合成或血管活性.
- 长期使用L-氨酸对间歇性音和PAD患者没有好处.
- 这些发现与之前观察到的潜在短期益处形成鲜明对比.
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