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Updated: Jul 14, 2026

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
08:46

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

"超级武装"的甘氨基基捐赠体:通过化来对硫甘氨基酸的构造性武装

Christian Marcus Pedersen1, Lars Ulrik Nordstrøm, Mikael Bols

  • 1Department of Chemistry, University of Aarhus, Langelandsgade 140, DK-8000 Aarhus C, Denmark.

Journal of the American Chemical Society
|July 3, 2007
PubMed
概括

大量的西里尔保护群 (TBS) 增强了甘氨酸供体的反应性,使复杂碳水化合物的有效合成成为可能. 这一突破为创造碳水化合物合成的"超级武装"捐赠者和接受者提供了新的战略.

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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles14:37

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Oligosaccharide Assembly01:24

Oligosaccharide Assembly

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Multiple sugar molecules that may or may...
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Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
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Phase II Reactions: Sulfation and Conjugation with α-Amino Acids

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Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones

Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
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