在虫和鱼前脑中保存的感觉神经分泌细胞类型:洞察下丘脑演变的洞察力
Kristin Tessmar-Raible1, Florian Raible, Foteini Christodoulou
1Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69012 Heidelberg, Germany. kristin.tessmar@embl.de
Cell
|July 3, 2007
概括
神经分泌大脑中心的神经分泌大脑中心
科学领域:
- 神经科学是一个神经科学.
- 进化生物学 进化生物学
- 发展生物学 发展生物学
背景情况:
- 神经分泌控制中心在各种动物类的前脑中至关重要.
- 这些关键大脑中心的进化起源在很大程度上仍未被探索.
研究的目的:
- 识别神经分泌大脑中心的保存成分,暗示家族遗传的古代起源.
- 为了比较Platynereis dumerilii和斑马鱼中的表达神经元.
主要方法:
- 在Platynereis和斑马鱼中对血管催化神经元的比较分析.
- 微RNA (miR-7) 和转录因子表达 (nk2.1,rx,otp) 的表征.
- 研究斑马鱼rx3在血管素-神经素表达中的作用.
主要成果:
- 在两种物种的血管性神经元中,miR-7和转录因子 (nk2.1,rx,otp) 的共享表达.
- miR-7还标记了白金鱼和斑马鱼共享的RFamidergic神经元.
- 血管新生神经元和RFamidergic神经元在藻和鱼类中都表现出感官功能.
结论:
- 保存的分子机制 (miR-7,转录因子) 构成了整个类型的神经分泌神经元的基础.
- 双重感官神经分泌细胞类型被认为是双胞胎中大脑神经分泌中心的进化起源.
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