慢性病:对心血管系统的影响
Ernesto L Schiffrin1, Mark L Lipman, Johannes F E Mann
1Department of Medicine, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada. ernesto.schiffrin@mcgill.ca
Circulation
|July 4, 2007
概括
慢性病通过高血压,脂质失调和糖尿病加速心血管疾病. 管理这些危险因素对于预防患者心脏病发作,中风和其他心血管事件至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 血管生物学 血管生物学
背景情况:
- 加快心血管疾病是慢性病 (CKD) 患者的常见并发症.
- 慢性病有助于高血压,脂质失调和糖尿病,这些都是内皮功能障碍和动脉样硬化的关键驱动因素.
- 糖尿病病是发达国家末期病的主要原因.
研究的目的:
- 要总结慢性病和加速心血管疾病之间的复杂关系.
- 突出将CKD与心血管并发症联系在一起的机制.
- 强调心血管疾病预防和管理在CKD患者中的重要性.
主要方法:
- 文献综述和综合关于CKD和心血管疾病的现有研究.
- 分析高血压,血脂不良,糖尿病,炎症和血管化在CKD相关动脉样硬化中的作用.
- 检查CKD对心血管疾病发病率和死亡率的影响.
主要成果:
- 慢性瘤通过诸如血压升高,脂质状况异常和糖尿病等因素加剧动脉样硬化.
- 在CKD中,氨酸- ангиотензин系统的炎症和激活有助于氧化应激和动脉样硬化.
- 在CKD中改变的化平衡促进了血管化和损伤,特别是在末期病中.
结论:
- 慢性瘤显著增加了心血管事件的风险,如心脏病发作,心力衰竭和中风.
- 有效管理高血压,脂质障碍和糖尿病对于减轻慢性病中心血管风险至关重要.
- 心血管疾病的预防和治疗是全面CKD护理的关键组成部分,以减少患者的发病率和死亡率.
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