儿童艾滋病毒感染的国际视角,进展和未来挑战
Andrew Prendergast1, Gareth Tudor-Williams, Prakash Jeena
1Department of Paediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK.
Lancet (London, England)
|July 10, 2007
概括
儿童艾滋病毒感染仍然是一个全球危机,发展中国家对干预措施的获取有限. 确保所有儿童都接受有效的抗逆转录病毒疗法对于打击儿童艾滋病毒/艾滋病至关重要.
科学领域:
- 儿童传染病 儿童传染病
- 全球健康 全球健康
- 免疫学 免疫学 免疫学
背景情况:
- 儿童艾滋病毒感染是一个重大的全球卫生挑战,每天新感染的数量很高.
- 发达国家 (<2%) 母婴传播率较低,但发展中国家 (25-40%) 的传播率较高.
- 在资源有限的环境中,妇女对干预措施的准入仍然非常低 (5-10%).
研究的目的:
- 突出儿童艾滋病毒感染的临床和免疫特征.
- 应对在全球范围内为儿童提供普遍获得有效干预措施的挑战.
- 强调需要公平地为艾滋病毒感染儿童提供抗逆转录病毒疗法.
主要方法:
- 对专门针对儿科艾滋病毒的临床和免疫学数据的审查.
- 对干预接入和传输率的全球差异分析.
- 检查抗逆转录病毒治疗对儿童艾滋病毒进展的影响.
主要成果:
- 未经治疗的儿科艾滋病毒进展迅速,在资源贫困的环境中死亡率高 (>50%在2年内).
- 抗逆转录病毒治疗可以改变儿科艾滋病毒的自然史,类似于成年人.
- 在全球儿童获得拯救生命的治疗方法方面存在重大差距.
结论:
- 迫切需要全球努力,以弥合儿童艾滋病毒干预措施获取的差距.
- 解决儿童的特定临床和免疫需求至关重要.
- 实现全民获得抗逆转录病毒疗法对于减少儿童艾滋病毒死亡率和疾病进展至关重要.
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