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禁食与非禁食的甘油三和女性心血管事件的风险相比
Sandeep Bansal1, Julie E Buring, Nader Rifai
1Donald W. Reynolds Center for Cardiovascular Research, Brigham and Women's Hospital, Boston, MA 02215, USA.
JAMA
|July 20, 2007
概括
不同于禁食时的甘油三水平,非禁食时的甘油三水平独立地与女性心血管事件风险增加有关. 这一发现凸显了非禁食三糖体测量对于心血管疾病风险评估的重要性.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 三甘油在心血管疾病 (CVD) 风险中的作用受到争议,特别是食后高甘油血的意义.
- 标准的脂质面板测量禁食甘油三,可能会忽视食后对动脉样硬化的影响.
研究的目的:
- 调查非禁食和禁食的甘油三水平与未来心血管事件的风险之间的关联.
- 为了确定非禁食的甘油三水平是否为心血管疾病风险提供独立的预测值.
主要方法:
- 一项针对26509名最初健康的美国女性进行的前性研究,来自"妇女健康研究".
- 在入学时测量了甘油三水平 (禁食和非禁食),平均随访时间为11.4年.
- 计算了发生心血管事件的危险比率,并根据各种风险因素进行了调整.
主要成果:
- 禁食和非禁食的甘油三水平与传统的心脏风险因素和胰岛素抵抗标志物在基线相关.
- 在完全调整的模型中,非禁食的甘油三水平与心血管事件有着强烈的,独立的关联.
- 在调整其他脂质和胰岛素抵抗标志物后,禁食甘油三水平显示出较弱的关联.
结论:
- 非禁食的甘油三水平与女性发生的心血管事件独立相关,超出了传统的危险因素和其他脂质测量措施.
- 禁食的甘油三水平在这个队列中表现出对心血管事件的最小独立预测值.
- 这些发现表明,非禁食的甘油三测量可能对全面的心血管风险评估至关重要.
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