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Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures
Published on: April 21, 2011
在边界细胞集体迁移期间,有两种不同的引导信号模式
Ambra Bianco1, Minna Poukkula, Adam Cliffe
1European Molecular Biology Laboratory, Heidelberg, 69117, Germany.
Nature
|July 20, 2007
概括
对于发育和转移至关重要的集体细胞迁移,在Drosophila边界细胞中进行了研究. 这项研究揭示了引导迁移的两个不同的阶段,涉及两极化的细胞行为和动态的集体行动,多细胞信息处理指导小组.
科学领域:
- 细胞生物学 细胞生物学
- 发育生物学 发展生物学
- 遗传学 是一个遗传学.
背景情况:
- 定向细胞迁移对于单个细胞和细胞组至关重要,但集体指导机制仍然不太清楚.
- 虽然单细胞迁移得到了很好的研究,但集体细胞迁移对胚胎发育和转移具有重要意义.
- 果虫边界细胞提供了一个模型系统来研究集体细胞指导.
研究的目的:
- 阐明Drosophila边界细胞中集体细胞指导的机制.
- 调查集体迁移所涉及的不同阶段和分子途径.
- 了解多细胞信息处理如何有助于引导细胞群行为.
主要方法:
- 在线成像和基因分析Drosophila边界细胞.
- 研究信号通路,包括PDGF和VEGF相关受体和表皮生长因子受体.
- 对肌细胞城市 (Mbc) 和吞和细胞运动 (ELMO) 途径的分析.
主要成果:
- 果虫边界细胞表现出两种不同的迁移阶段:一个由两极化的细胞行为驱动的早期阶段和一个由动态集体行为主导的后期阶段.
- 特定的信号通路 (PDGF/VEGF相关受体,EGF受体) 在每个阶段都被不同的方式利用.
- 肌细胞城市 (Mbc) 和吞和细胞运动 (ELMO) 途径对于早期迁移阶段至关重要.
- 在后期阶段,使用冗余的基因激活蛋白激酶和脂酶Cgamma通路,细胞对细胞信号水平差异指导迁移.
结论:
- 集体细胞指导涉及不同的时间阶段,具有独特的潜在机制.
- 多细胞信息处理,利用细胞组内的信号水平差异,对于引导集体迁移至关重要.
- 了解这些机制可以深入了解发育过程和癌症转移等疾病.
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