共同的效应器处理调解了细胞对刺激的特定反应
Kathryn Miller-Jensen1, Kevin A Janes, Joan S Brugge
1Center for Cell Decision Processes, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Nature
|July 20, 2007
概括
细胞特异性信号响应源于常见下游效应因子的上游差异性激活. 这个原理解释了多样化的细胞表型,并有助于开发针对信号功能障碍的向疗法.
科学领域:
- 细胞生物学 细胞生物学
- 系统生物学 系统生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 细胞内信号通路在细胞之间共享共同的组件.
- 刺激这些途径会导致细胞特异的表型,使药物开发复杂化.
- 了解细胞特异性对于向疗法至关重要.
研究的目的:
- 研究细胞特异性信号事件如何通过效应器集成,产生不同的结果.
- 分析瘤亡因子和腺病毒载体之间的协同作用,以寻找细胞特异性反应.
- 开发用于细胞特异信号的预测模型.
主要方法:
- 应用系统建模方法来分析细胞内网络.
- 构建模型以估计通过效应基质处理成表型的激酶信号.
- 利用了部分最小平方回归模型.
主要成果:
- 当细胞类型具有共同的效应器处理机制时,可以准确地预测细胞特异性.
- 模型成功地预测了细胞特异性亡,化学激素释放,基因诱导和药物敏感性.
- 证明的细胞特异性源于上游传感器的差异激活.
结论:
- 细胞特异性来自于差异上游激活,使共同的作用因子能够产生不同的结果.
- 共同的效应器处理是细胞生物学的一个关键原则.
- 这个原则适用于了解细胞特异性药物反应和开发向疗法.
相关概念视频
Cell-mediated Immune Responses
Overview
Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Diversity in Cell Signaling Responses
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Antigen Processing Pathways
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...


