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Preparation of Biopolymer Aerogels Using Green Solvents
Published on: July 4, 2016
通过结合立体复合和光聚合,在现场迅速形成可生物降解的坚固水凝
Christine Hiemstra1, Wei Zhou, Zhiyuan Zhong
1Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, Institute for Biomedical Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Journal of the American Chemical Society
|July 25, 2007
概括
这项研究结合了立体复合和光聚合,以创建强大的,快速形成的水凝. 这些先进的水凝为生物医学应用提供了增强的机械性能和长时间的降解.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 材料工程 材料工程 材料工程
背景情况:
- 聚乙烯糖醇-聚乳酸 (PEG-PLA) 共聚合物的立体复合形成水凝.
- 在生物医学应用中,在现场形成水凝是理想的.
- 结合交叉连接方法可以增强水凝的特性.
研究的目的:
- 通过结合立体复合和光聚合,在现场快速发展,形成强大的水凝.
- 为了研究甲基酸盐功能化位置对水凝性质的影响.
- 评估组合水凝的机械性能和降解概况.
主要方法:
- 设计和合成甲基烯酸功能化的PEG-PLLA和PEG-PDLA星块共聚合物.
- 在混合共聚合物溶液时快速形成立体复杂的水凝.
- 随后对立体复合水凝进行光聚合.
- 水凝储存模块的特征,胀和降解行为.
主要成果:
- 在12.5-17.5% (w/v) 的聚合物度下实现了快速的水凝形成 (1-2分钟).
- 结合立体复合和光聚合,与单一方法相比,存储模块显著增加.
- 存储模块随着立体复杂化时间线性增加,表明了协同作用.
- 光聚合在非常低的启动度 (0.003重量%) 时有效.
- 组合水凝的降解时间较长 (3-16周以上),而光聚化水凝的降解时间较长 (1.5周).
结论:
- 结合立体复合和光聚合是一种新的策略,可以快速在现场形成,强大的水凝.
- 甲基酸盐功能化的位置会影响降解速率.
- 这些先进的水凝对于需要快速形成,机械强度和受控降解的应用具有前景.
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