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Updated: Jul 13, 2026

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由RNase L生成的小自RNA增强了抗病毒天生的免疫力

Krishnamurthy Malathi1, Beihua Dong, Michael Gale

  • 1Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA.

Nature
|July 27, 2007
PubMed
概括

通过2-5A激活RNase L,产生自我RNA片段,触发抗病毒干扰素 (IFN) 生产. 缺乏RNase L的小鼠对病毒感染的IFN-β反应受损,突出显示RNase L.

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