伊米多二酸盐和酸盐:类似结构的可能生物学意义
M Larsen1, R Willett, R G Yount
1Department of Chemistry, Washington State University, Pullman 99163, USA.
Science (New York, N.Y.)
|December 19, 1969
概括
二二酸盐的结构非常类似于二酸盐. 这种相似性解释了为什么以前没有检测到藻类多酸盐中的PNP链接,以及为什么具有这种链接的ATP类似物模仿ATP.
科学领域:
- 无机化学 无机化学 无机化学
- 结构化学 结构化学
- 生物化学 生物化学
背景情况:
- 酸盐具有P-O-P连接,在生物能量转移中至关重要.
- 藻类多酸盐含有P-N-P链接,但它们与火酸盐的结构和功能相似性尚未完全理解.
研究的目的:
- 为了确定二二酸盐的晶体结构.
- 为了比较P-N-P链接的结构参数与酸盐中的P-O-P链接.
主要方法:
- 用单晶X射线衍射分析了二二酸盐的结构.
主要成果:
- 在二二酸盐中确定了PNP结合角度 (127.2°) 和PN结合距离 (1.68 Å).
- 这些值与精制的P-O-P结合角度 (128.6°) 和P-O结合距离 (1.63 Å) 非常相似.
结论:
- P-N-P和P-O-P链接之间的结构相似性解释了在藻类多酸盐中延迟检测P-N-P键的原因.
- 这种结构类比也解释了由含有PNP链接的类似物模仿腺三酸盐 (ATP) 的功能模仿.
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