跨膜信号工具包中的一个新的扭曲
Mark A Lemmon1, Kathryn M Ferguson
1Department of Biochemistry & Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. mlemmon@mail.med.upenn.edu
Cell
|July 31, 2007
概括
晶体结构揭示了干细胞因子 (SCF) 如何通过驱动二分化来激活Kit受体氨酸激酶. 这些发现还揭示了基特突变如何促进癌症的发展.
科学领域:
- 生物化学 生物化学
- 结构生物学 结构生物学
- 分子生物学分子生物学
背景情况:
- 基特受体氨酸激酶在细胞信号通路中起着至关重要的作用.
- 基特信号的失调与各种癌症有关.
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