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在患有家族性高胆固醇血症的儿童中使用静止剂治疗:越年轻,越好.

Jessica Rodenburg1, Maud N Vissers, Albert Wiegman

  • 1Academic Medical Centre, Department of Vascular Medicine, University of Amsterdam, The Netherlands.

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概括

在患有家族性高胆固醇血症的儿童中,早期使用他类药物治疗显著降低了动脉内心介质厚度 (IMT) 的进展. 这项长期研究证实,早期开始服用他类药物对预防青少年动脉样硬化有益.

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科学领域:

  • 心血管医学 心血管医学
  • 儿科内分泌学 儿科内分泌学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 之前的随机试验表明,在患有家族性高胆固醇血症的儿童中,普拉瓦斯塔丁可逆转心室内介质厚度 (IMT).
  • 启动了长期随访研究,以评估他类药物启用年龄对心血管IMT的影响.
  • 在儿科患者中长期使用他类药物治疗的安全性也得到了评估.

研究的目的:

  • 探索他类药物开始的年龄与动脉IMT之间的关系.
  • 评估普拉瓦斯塔丁治疗在患有家族性高胆固醇血症儿童的长期安全性和疗效.

主要方法:

  • 从先前的安慰剂对照试验中对214名儿童的随访,其中186人提供了分析数据.
  • 儿童在初步研究后继续接受普拉瓦斯塔丁治疗 (20或40毫克).
  • 在平均4.5年内,监测了心内脉的IMT测量和安全参数 (脂质,实验室测试).

主要成果:

  • 开始服用他类药物的年龄是随访后 carotid IMT 的独立预测因素.
  • 较早启动他类药物治疗与较小的动脉IMT有关.
  • 没有报告任何严重的实验室不良事件;他类药物治疗没有影响性成熟.

结论:

  • 在青少年和年轻成年人中,早期启动他类药物治疗会延迟动脉IMT的进展.
  • 这项研究提供了证据表明,在患有家族性高胆固醇血清症的儿童早期使用他类药物治疗可以预防青春期的动脉样硬化.