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不同类型的染色体重组会在前列腺癌中产生瘤性ETS基因融合

Scott A Tomlins1, Bharathi Laxman, Saravana M Dhanasekaran

  • 1Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

Nature
|August 3, 2007
PubMed
概括

研究人员在前列腺癌中发现了新的基因融合,通过基因组重组激活了ETV1瘤基因. 这种ETV1过度表达驱动瘤的发展,并可能影响抗雄激素治疗的有效性.

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