在植物应激和能量信号中作为转录网络的中心集成者
Elena Baena-González1, Filip Rolland, Johan M Thevelein
1Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston Massachusetts 02114, USA. baena@molbio.mgh.harvard.edu
Nature
|August 3, 2007
概括
植物蛋白激酶KIN10和KIN11将黑暗,糖和压力信号联系起来,以控制植物的生长和生存. 这些激酶被糖不活性化,在能量信号传递中发挥关键作用.
科学领域:
- 植物生物学 植物生物学
- 分子遗传学 分子遗传学
- 生物化学 生物化学
背景情况:
- 植物是主要的太阳能转换器,对生命至关重要.
- 了解植物适应黑暗,压力和能量耗尽的情况至关重要.
- 现有的模型侧重于各种压力感知和信号通路.
研究的目的:
- 为了研究阿拉比多普西斯莉亚的蛋白激酶KIN10和KIN11.11的作用.
- 了解这些激酶如何调节转录重编程以响应环境线索.
- 阐明KIN10/11在能源信号和植物适应中的作用.
主要方法:
- 在Arabidopsis thaliana中使用了蜂和系统屏幕.
- 进行了KIN10和KIN11的功能分析,包括基因缺陷和过度表达.
- 研究了转录重编程,基因向和代谢调节.
主要成果:
- KIN10和KIN11在对黑暗,糖和压力的反应中编排转录.
- KIN10的目标是参与催化作用的基因,并抑制催化作用,部分由bZIP转录因子介导.
- 过度表达KIN10增强了饥饿耐受性和寿命;kin10 kin11突变体显示暗适应,粉调动和生长受损.
结论:
- KIN10/11在将压力,糖和发育信号联系起来至关重要,以调节植物新陈代谢,能量平衡,生长和生存.
- 与普遍观点相反,植物SnRK1s (包括KIN10/11) 被糖无活化.
- 在能量信号传递中,KIN10/11与酵母Snf1和哺乳动物AMPK共享核心作用.
相关概念视频
Cell Signaling in Plants
6.0K
Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
6.0K
Plant Hormones
26.4K
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
26.4K
Transcription
153.6K
Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
153.6K
Responses to Heat and Cold Stress
14.3K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
14.3K
Short-distance Transport of Resources
17.1K
Short-distance transport refers to transport that occurs over a distance of just 2-3 cells, crossing the plasma membrane in the process. Small uncharged molecules, such as oxygen, carbon dioxide, and water, can diffuse across the plasma membrane on their own. In contrast, ions and larger molecules require the assistance of transport proteins due to their charge or size. Transport across membranes also occurs within individual cells, playing a variety of essential roles for the plant as a whole.
17.1K
Stress Response System
499
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
Alarm stage
In the alarm stage, the body's...
499


