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Updated: Jun 25, 2026

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三螺旋过渡状态类似物:一种新的选择性矩阵金属蛋白酶抑制剂类别

Janelle Lauer-Fields1, Keith Brew, John K Whitehead

  • 1Department of Chemistry and Biochemistry and College of Biomedical Sciences, Florida Atlantic University, Boca Raton, Florida 33431, USA.

Journal of the American Chemical Society
|August 4, 2007
PubMed
概括

研究人员开发了一种新型的酸三螺旋抑制剂,向矩阵金属蛋白酶 (MMP),特别是MMP-2和MMP-9. 这种新型的蛋白酶抑制剂对凝酶具有很高的亲和力和选择性,为癌症治疗提供了一个有前途的策略.

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