概括
使用环胺和子抗血清的免疫抑制可以防止Theiler引起的脱髓化.
科学领域:
- 神经免疫学 神经免疫学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- 泰勒病毒感染小鼠导致中枢神经系统脱髓化.
- 在这种病毒模型中,驱动脱髓化的精确机制尚未完全理解.
研究的目的:
- 为了研究免疫系统在泰勒病毒诱导的脱髓化中的作用.
- 为了确定免疫抑制是否可以预防脱髓化.
主要方法:
- SJL/J小鼠感染了泰勒病毒.
- 小鼠接受了用环胺和子抗血清对小鼠胸细胞的免疫抑制治疗.
- 通过使用1微米Epon嵌入截面分析中枢神经系统组织.
主要成果:
- 免疫抑制有效地消除了脊髓白质中的单核细胞透物.
- 免疫抑制治疗完全阻止了脱髓化的发展.
- 脱髓化缺失与免疫细胞透的减少相关.
结论:
- 在SJL/J小鼠中由Theiler病毒诱导的脱林化是一个免疫媒介的过程.
- 针对免疫反应可能是病毒诱导的脱髓化治疗策略.
相关概念视频
Cell-mediated Immune Responses
Overview
Infection
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
B Cell Activation and Differentiation
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Toxoplasmosis
Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...


