在中风或过渡性缺血性攻击患者中,大动脉动瘤进展和复发性血管事件
Souvik Sen1, Alan Hinderliter, Pranab K Sen
1Department of Neurology, University of North Carolina, Chapel Hill, USA. SenS@neurology.unc.edu
Circulation
|August 9, 2007
概括
在中风或TIA患者中,大动脉动脉瘤的进展与血管事件的增加有关. 这一发现凸显了对这些高风险个体动脉瘤的监测的重要性.
科学领域:
- 心血管医学 心血管医学
- 神经学 神经学
- 血管生物学 血管生物学
背景情况:
- 大动脉门 (AA) 动脉瘤是脑血管事件的已知危险因素.
- 在中风/TIA患者中,AA动脉瘤进展和随后的血管事件之间的关联仍然不清楚.
研究的目的:
- 调查AA动脉瘤的进展是否与患有中风或暂时性缺血性攻击 (TIA) 的患者的复发性血管事件有关.
主要方法:
- 评估了167名中风/TIA和基线AA动脉动脉动瘤的患者,这些患者接受过食道心电图 (TEE) 的评估.
- 117名患者接受了12个月的随访TEE.
- 评估了AA动脉瘤的进展情况,并对患者进行了血管事件的跟踪.
主要成果:
- 在12个月内,在28%的患者中观察到AA动脉瘤进展.
- 进展与更高的同型半氨酸和中性粒细胞水平有关.
- 患有AA动脉瘤进展的患者有明显更高的复合血管事件发生率 (HR 5.8,P=0.0002).
结论:
- 大动脉动脉瘤的进展与有中风或TIA史的患者的复发性血管事件有关.
- 这项初步研究表明,监测AA动脉瘤进展可能对中风/TIA患者的风险分层很重要.
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