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Updated: May 8, 2026

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Published on: June 28, 2018

一个IRF8结合促进子变体和AIRE控制CHRNA1在胆乳腺中的乱交表达

Matthieu Giraud1, Richard Taubert, Claire Vandiedonck

  • 1Inserm, U580, 75015 Paris, France.

Nature
|August 10, 2007
PubMed
概括

一种新的CHRNA1基因促进器变异通过阻止IRF8结合来破坏耐受性,导致早期发生的自身免疫性骨髓灰质炎. 这突显了AIRE和干扰素途径在调节自身抗原表达和自我耐受性方面.

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