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Updated: Jul 9, 2026

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
12:21

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram

Published on: November 27, 2016

LeuT-desipramine结构揭示了抗抑郁药如何阻断神经递质再吸收

Zheng Zhou1, Juan Zhen, Nathan K Karpowich

  • 1Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.

Science (New York, N.Y.)
|August 11, 2007
PubMed
概括

三环抗抑郁药,如迪西普拉,通过与传递体内结合来阻断神经递质运输体,防止构造变化和基质运输. 这种机制很可能保留在人类的血清素和多巴胺载体中.

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Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model08:15

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