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系统地探索影响DNA化和生物活性的雅塔基的结构特征

Mark S Tichenor1, Karen S MacMillan, John D Trzupek

  • 1Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|August 19, 2007
PubMed
概括

亚塔基的独特的三明治结构显著提高了DNA化效率,并强化了细胞毒性活性. 亚单元替代剂对药物的疗效不如这种安排那么重要.

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