骨架对能量代谢的内分泌调节
Na Kyung Lee1, Hideaki Sowa, Eiichi Hinoi
1Department of Genetics & Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Cell
|August 19, 2007
概括
骨架可以调节糖的平衡. 骨中的骨质素可以提高胰岛素敏感性和葡萄糖耐受性,而缺少它会导致代谢功能障碍,突出骨.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 骨生物学 骨生物学 骨生物学
背景情况:
- 脂肪细胞衍生的荷尔蒙调节骨重塑,这表明骨可能会影响能量恒温.
- 骨质母细胞表达影响能量代谢的信号分子.
研究的目的:
- 研究骨质细胞衍生因素在调节能量代谢和葡萄糖平衡中的作用.
- 确定OST-PTP和骨质卡尔对代谢参数的影响.
主要方法:
- 对缺乏OST-PTP或骨质素的转基因小鼠进行分析.
- 对β细胞增殖,胰岛素分泌和胰岛素敏感性的评估.
- 在体外和体内实验中评估骨质卡尔对β细胞和脂肪细胞的影响.
主要成果:
- 缺乏OST-PTP的小鼠表现出低血糖症,对肥胖的保护,以及由于增强的β细胞功能和胰岛素敏感性而改善的葡萄糖耐受性.
- 缺乏骨质卡尔的小鼠表现出葡萄糖耐受性和胰岛素抵抗性受损.
- 骨质卡尔的使用改善了葡萄糖耐受性,并刺激了胰岛素和阿迪波内克丁的表达.
结论:
- 骨架对糖的平衡产生内分泌调节.
- 骨质素是骨对能量代谢影响的关键调解剂.
- 这项研究扩展了已知的骨生物功能,以及我们对代谢调节的理解.
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