神经列车之间的相关性随着发射速度的增加而增加
Jaime de la Rocha1, Brent Doiron, Eric Shea-Brown
1Center for Neural Science, New York University, New York 10003, USA. jrocha@cns.nyu.edu
Nature
|August 19, 2007
概括
神经发射速度,而不是变化,决定了神经元之间的相关激增. 这一发现揭示了神经元发射率和相关活动之间的根本联系,影响了我们对神经代码的理解.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 在各种大脑区域中观察到神经元动作潜力的时间相关性 (尖峰列车).
- 相关的发射涉及到诸如刺激编码,注意力和运动控制等关键功能.
- 关联升的精确机制和编码含义仍然不完全理解,特别是输入特征的影响.
研究的目的:
- 调查尖端列车输出相关性是否仅取决于输入电流相关性,还取决于输入平均值和方程.
- 阐明神经网络中输入相关性,发射率和输出相关性之间的关系.
主要方法:
- 对未连接的实验室皮层神经元对接到相关输入的计算尖峰列车相关系数.
- 采用分析技术和使用"整合和发射"神经元模型的数值模拟.
- 使用标准值线性神经元模型验证的结果.
主要成果:
- 尖端列车输出相关性随着发射速度的增加而增加,即使输入相关性是恒定的.
- 产出相关性在很大程度上独立于尖端列车变化.
- 输出相关性和发射率之间的观察到的关系被证明是对输入异质性的强大.
结论:
- 神经元发射率,而不是输入变化,是相关升的关键决定因素.
- 这项研究揭示了先前被忽视的激发率与神经活动的相关性之间的显著关系.
- 这些发现将神经代码的两个基本方面联系起来:尖端速率和相关性,提供了更统一的理解.
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