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Nucleocapsid Annealing-Mediated Electrophoresis (NAME) Assay Allows the Rapid Identification of HIV-1 Nucleocapsid Inhibitors
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从2-mercaptobenzamide thioesters转移到HIV-1核体蛋白的乙烯基转移的特异性

Lisa M Miller Jenkins1, Toshiaki Hara, Stewart R Durell

  • 1Laboratory of Cell Biology, NCI, and Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.

Journal of the American Chemical Society
|August 21, 2007
PubMed
概括

针对HIV-1核体蛋白 (NCp7) 的新型抗逆转录病毒药物候选药物显示了特定的相互作用. 这些2-mercaptobenzamide thioester化合物排出,并为抗突变疗法提供基础.

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Acetylation, a phase II biotransformation reaction, introduces an acetyl group to drugs or their metabolites. Acetyltransferase enzymes facilitate this reaction, which resembles α-amino acid conjugation due to the addition of a functional group to the drug molecule.
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