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相关概念视频

Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last for...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

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相关实验视频

Updated: Jul 12, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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在使用Taxus支架进行冠状动脉动脉增生术后,切莱科西布对静止病的影响 (COREA-TAXUS试验):一项开放式随机对照研究.

Bon-Kwon Koo1, Yong-Seok Kim, Kyung-Woo Park

  • 1Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Center and Cardiovascular Research Institute, Seoul National University Hospital, Seoul, South Korea.

Lancet (London, England)
|August 21, 2007
PubMed
概括

赛莱科克西布是一种循环氧化酶2抑制剂,降低了冠状动脉支架中的新心血管形成. 这项研究发现,在患有冠状动脉疾病的患者中,切莱科西布在减少目标病变重血管化方面是安全有效的.

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Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China
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科学领域:

  • 心血管医学 心血管医学
  • 干预心脏病学 干预心脏病学
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 实验室和动物研究表明,赛莱科西布 (一种循环氧化酶2抑制剂) 可能会降低支架内新内膜的形成.
  • 需要临床数据来确认在接受冠状动脉支架的患者中这些影响.

研究的目的:

  • 评估赛莱科克西布在冠状动脉支架植入后减少新内形成的疗效和安全性.
  • 评估赛莱科克西布对临床结果的影响,例如目标病变的再血管化.

主要方法:

  • 一个随机的,两中心试验,涉及274名冠状动脉疾病患者.
  • 患者接受了阿司匹林和克洛皮多格雷尔;136人被分配给塞莱科克西布 (400毫克负载,200毫克两次每天6个月),以及帕克利塔塞尔排泄支架.
  • 主要终点:通过定量冠状动脉血管学,在6个月的晚期光线损失.

主要成果:

  • 在6个月后,与对照组 (0.75毫米) 相比,塞莱科克西布组 (0.49毫米) 的平均晚期静脉损失显着较低.
  • 塞莱科克西布组显示了二次结果的频率降低,主要是由于对目标损伤再血管化的需求减少.

结论:

  • 对于冠状动脉疾病患者,在支架植入后6个月内辅助使用赛莱科克西布似乎是安全的.
  • 切莱科克西布治疗表明,减少了对目标病变再血管化的需要,这表明它在支架结果中起着有益的作用.