与Dnmt3L结合的Dnmt3a的结构表明了新的DNA甲基化模式

Da Jia1, Renata Z Jurkowska, Xing Zhang

  • 1Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322, USA.

Nature
|August 24, 2007
PubMed
概括

DNA甲基转移酶3类蛋白 (Dnmt3L) 激活DNA甲基转移酶3a (Dnmt3a),以建立基因组印记. 它们在DNA上的相互作用和寡合化产生了一个周期性甲基化模式,这对于印记基因调节至关重要.

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