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Updated: Jul 12, 2026

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
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Published on: October 13, 2022

在液晶介质中调节蛋白质对齐,通过保守的突变发生

Lishan Yao1, Ad Bax

  • 1Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Deseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA.

Journal of the American Chemical Society
|August 28, 2007
PubMed
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No abstract available in PubMed .

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Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...