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过渡性四肢缺血诱导远程预调和远程后调在人类通过一个K ((ATP) 通道依赖的机制
Stavros P Loukogeorgakis1, Rupert Williams, Anna T Panagiotidou
1Vascular Physiology Unit, Institute of Child Health, University College London, 34 Great Ormond St, London, WC1N 3JE, UK. s.loukogeorgakis@ich.ucl.ac.uk
Circulation
|August 29, 2007
概括
人类的远程后调节 (RPostC),由短暂的四肢缺血引起,有效地防止内皮缺血-再输液 (IR) 损伤. 这种保护效应类似于远程缺血预制 (RIPC),依赖于K(ATP) 通道激活.
科学领域:
- 心血管研究研究心血管研究
- 身体生理学 身体生理学
- 细胞生物学 细胞生物学
背景情况:
- 远程缺血预调 (RIPC) 提供了对缺血-再输液 (IR) 损伤的系统性保护.
- 远程后调节 (RPostC) 涉及在受伤事件期间应用短暂的缺血,以提供保护.
- 人类RPostC的发生和机制以前是未确定的.
研究的目的:
- 调查RPostC是否可以在人类中使用过渡性四肢缺血来诱导.
- 为了比较RPostC与RIPC在预防内皮膜IR损伤方面的疗效.
- 探索RIPC和RPostC之间共享的机制路径.
主要方法:
- 在IR之前和之后通过流介导扩张评估了内皮功能.
- 在IR之前,四肢缺血/再输循环诱导了RIPC.
- 在IR阶段,肢体缺血/再输循环诱导了RPostC.
- 使用口服 Glibenclamide 评估了 K (((ATP) 通道的作用.
主要成果:
- 在健康志愿者和动脉样硬化患者中,IR显著降低了内皮功能.
- 无论是RIPC还是RPostC都有效地防止了IR引起的内皮功能减弱.
- RIPC和RPostC的保护作用被glibenclamide消除,表明K ((ATP)) 通道依赖.
结论:
- 远程后调节 (RPostC) 在人类中是可以实现的,并有效地减轻内皮内射损伤.
- 在防止IR损伤方面,RPostC的有效性与RIPC相美.
- 无论是RIPC还是RPostC,都有一个共同的机制,包括K ((ATP) 通道激活.
- 远程调节策略有望保护接受急性缺血和再注射治疗的患者.
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