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在小鼠中通过与人体同等剂量的氨醇产生的口腔裂

Science (New York, N.Y.)

|August 20, 1965

概括

一种葡萄糖皮质类药物Triamcinolone在与人类相当的剂量下,在小鼠胚胎中引起口腔裂变,这表明其具有很高的致病性. 其他测试的葡萄糖皮质激素,包括脱氧皮质,没有显示类似的效果.

科学领域:

发展性毒理学发展性毒理学
药理学药理学是指药理学的学科.
甲状腺学甲状腺学

背景情况:

葡萄糖皮质类药物广泛用于治疗,但在怀孕期间可能会带来风险.
评估不同葡萄糖皮质激素的原性潜力对于药物安全至关重要.

研究的目的:

为了在小鼠模型中比较triamcinolone与其他葡萄糖皮质激素的产性作用.
评估在治疗上相关剂量中使用triamcinolone诱导的口腔裂形成的风险.

主要方法:

在关键发育时期,给孕小鼠服用不同剂量的氨和脱氧皮质.
胚胎检查是否存在发育异常,特别是口腔裂.

主要成果:

氨在小鼠胚胎中诱导了口腔裂,剂量与人类治疗水平相当.
与其他经过测试的葡萄糖皮质类药物相比,氨显示出显著更高的产性.
德索西皮质在广泛的剂量范围内没有导致口腔裂的形成.

结论:

在临床相关的暴露水平下,氨具有显著的致病风险,特别是在 palatal 发育方面.
这些发现突显了葡萄糖皮质类药物之间差异性的原性潜力,强调了需要仔细评估风险和益处的需要.

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