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Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
Proofreading01:43

Proofreading

Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
Termination of Translation01:44

Termination of Translation

The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
Proofreading01:31

Proofreading

Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Variance01:15

Variance

The deviations show how spread out the data are about the mean. A positive deviation occurs when the data value exceeds the mean, whereas a negative deviation occurs when the data value is less than the mean. If the deviations are added, the sum is always zero. So one cannot simply add the deviations to get the data spread. By squaring the deviations, the numbers are made positive; thus, their sum will also be positive.The standard deviation measures the spread in the same units as the data.

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相关实验视频

Updated: Jul 6, 2026

Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

这就是Erratum Erratum.

    Science (New York, N.Y.)
    |February 8, 1991
    PubMed
    概括

    像和这样的天然毒素,通常在高水平上发现,在历史上被忽视. 研究工作集中在微量工业污染物上,忽略了重要的天然致癌物.

    科学领域:

    • 环境科学 环境科学
    • 毒理学 毒理学 毒理学
    • 公共卫生 公共卫生

    背景情况:

    • 关于工业污染物的担忧往往掩盖了自然存在的毒素.
    • 在各种地点确定了水中的高水平天然和室内空气中的.
    • 历史上,研究工作的重点不成比例地集中在工业污染物上,而不是自然环境危害.

    研究的目的:

    • 纠正和澄清以前关于自然污染物与工业污染物的相对重要性的陈述.
    • 突出在环境健康研究中历史上忽视了重要的天然致癌物质.
    • 强调需要在评估环境风险时采取平衡的方法.

    主要方法:

    • 审查和纠正已发表的科学通信.
    • 分析环境毒理学的历史研究重点.
    • 与自然和工业污染物相关的风险因素的比较评估.

    主要成果:

    • 确定了有关环境毒素的公布信件的具体纠正.
    • 强调,尽管天然和的患病率很高,但却被忽视.
    • 展示了对工业污染物在微小水平上的历史关注.

    结论:

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    Last Updated: Jul 6, 2026

    Molecular Evolution of the Tre Recombinase
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    Molecular Evolution of the Tre Recombinase

    Published on: May 29, 2008

    Development of an Experimental Setup for the Measurement of the Coefficient of Restitution under Vacuum Conditions
    07:49

    Development of an Experimental Setup for the Measurement of the Coefficient of Restitution under Vacuum Conditions

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    • 和等天然毒素对环境健康构成重大风险.
    • 需要对研究重点进行重新评估,以应对高水平的自然环境危险.
    • 对自然和工业污染物的平衡考虑对于有效的公共卫生战略至关重要.