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Updated: Jul 9, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
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鼠类的基尿:行为缺陷的可逆性

V J Polidora, R F Cunningham, H A Waisman

    Science (New York, N.Y.)
    |January 14, 1966
    PubMed
    概括

    基尿症 (PKU) 在大鼠中,由高氨饮食诱导,导致暂时的学习缺陷. 这些行为变化在停止饮食后逆转,质疑模型.

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    Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...