相关实验视频
Updated: Jul 6, 2026
12:02
Molecular Evolution of the Tre Recombinase
Published on: May 29, 2008
这就是Erratum Erratum
Science (New York, N.Y.)
|October 8, 1982
概括
这份报告纠正了先前关于人类白细胞转换的出版物. 表1中修正的列标题指定了细胞标记物,这些细胞标记物对于理解T细胞白血病病毒相互作用至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 细胞生物学 细胞生物学
背景情况:
- 成人T细胞白血病病毒 (ATLV) 是一种与特定白血病相关的人类逆转录病毒.
- 了解ATLV的白细胞转化需要精确识别细胞表面标记物.
- 之前关于白细胞转化通过ATLV的研究结果是由N. Yamamoto等人发表的.
研究的目的:
- 纠正N. Yamamoto等人的报告表1中的列标题.
- 为了确保通过ATLV.在人类白细胞转化研究中使用的细胞表面标记物的准确表示.
主要方法:
- 人类白细胞与ATLV生产细胞系共培养.
- 使用流细胞计,对转化白细胞上的细胞表面标记物的分析.
- 修正表1中之前报告的列标题.
主要成果:
- 表1中的"带标记的细胞 (%) "的列标题是不准确的.
- 修正后的标题是: Leu 1, Leu 2a, Leu 3a, Leu 4 和 Ia.
- 标记"免疫球蛋白A"被错误列出,应该用"Ia"代替.
结论:
- 对细胞表面标记物的准确报告对于免疫学研究的可重现性和解释性至关重要.
- 这种纠正澄清了涉及ATLV介导转换的特定白细胞子集.
- 修正后的数据支持进一步研究成年T细胞白血病的发病因子.
相关概念视频
01:43Proofreading
Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
01:43Proofreading
Synthesis of new DNA molecules starts when DNA polymerase links nucleotides together in a sequence that is complementary to the template DNA strand. DNA polymerase has a higher affinity for the correct base to ensure fidelity in DNA replication. The DNA polymerase furthermore proofreads during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.Errors during Replication Are Corrected by the DNA Polymerase EnzymeGenomic DNA is synthesized in...
01:44Termination of Translation
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
01:44Termination of Translation
The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...
01:31Proofreading
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore, it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Errors During Replication are Corrected by the DNA Polymerase Enzyme
01:15Variance
The deviations show how spread out the data are about the mean. A positive deviation occurs when the data value exceeds the mean, whereas a negative deviation occurs when the data value is less than the mean. If the deviations are added, the sum is always zero. So one cannot simply add the deviations to get the data spread. By squaring the deviations, the numbers are made positive; thus, their sum will also be positive.The standard deviation measures the spread in the same units as the data.