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相关概念视频

Genetic Lingo01:11

Genetic Lingo

Overview
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

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High-throughput Yeast Plasmid Overexpression Screen
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Published on: July 27, 2011

阿尔茨海默氏症,三形21和骨髓增殖性疾病:这些关联表明遗传病变.

L L Heston

    Science (New York, N.Y.)
    |April 15, 1977
    PubMed
    概括

    遗传缺陷可能会使个体易患阿尔茨海默病,三综合症21和骨髓增殖性疾病. 这些情况可能源于影响细胞微管的共同原因.

    科学领域:

    • 遗传学 是一个遗传学.
    • 细胞生物学 细胞生物学
    • 神经学 神经学

    背景情况:

    • 阿尔茨海默病 (AD) 是一种进展性神经退行性疾病.
    • 三胞胎症21 (唐氏综合征) 是一种与智力障碍和某些健康状况风险增加相关的遗传疾病.
    • 骨髓增殖性疾病 (MPD) 是一组影响血液细胞的癌症.

    研究的目的:

    • 调查阿尔茨海默氏症,三症21和骨髓增殖性疾病的潜在共同遗传基础.
    • 探索微管在这些看似不同的疾病的发病过程中的作用.

    主要方法:

    • 观察性研究分析了阿尔茨海默病患者的亲属的发病率.
    • 关于阿尔茨海默氏症,三位症21和MPD的细胞和遗传方面的文献综述.
    • 基于观察到的相关性和已知的生物途径生成假设.

    主要成果:

    • 阿尔茨海默病患者的亲属表现出更高的三发性21的发病率.
    • 在这些亲属中,骨髓扩散性疾病的发生率增加也被注意到.
    • 微管被确定为潜在的细胞结构,涉及到这些条件.

    结论:

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    • 一个共享的遗传缺陷可能会使个体易患阿尔茨海默病,三综合症21和骨髓增殖性疾病.
    • 这种潜在的遗传因素可能会影响微管的功能.
    • 需要进一步的研究来阐明涉及的特定分子机制.