相关实验视频
国际COPD流行率变化 (BOLD研究):以人口为基础的流行率研究
A Sonia Buist1, Mary Ann McBurnie, William M Vollmer
1Oregon Health and Sciences University, Portland, OR 97239, USA. BOLD@kpchr.org
Lancet (London, England)
|September 4, 2007
概括
这项全球性研究发现,晚期慢性阻塞性肺病 (COPD) 的患病率为10.1%. 年龄和吸烟是关键的危险因素,但其他因素也导致了全球COPD的流行.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 全球健康 全球健康
背景情况:
- 慢性阻塞性肺病 (COPD) 是一个重要的全球健康问题,导致发病率和死亡率.
- 准确的流行数据对于预测未来的疾病负担,识别风险因素和规划医疗服务至关重要.
研究的目的:
- 为了确定COPD的全球流行率.
- 调查年龄,性别和吸烟状况作为COPD风险因素的作用.
- 检查不同国家COPD患病率的变化.
主要方法:
- 来自12个国际地点的9,425名参与者接受了支气管扩展器后螺旋测量,并填写了问卷.
- 使用全球慢性阻塞性肺病倡议 (GOLD) 标准估计了COPD患病率,并根据目标人群进行了调整.
- 使用后勤回归和元分析来评估年龄和吸烟包年与COPD的关联,计算调整的几率比率 (OR).
主要成果:
- 第二阶段或更高COPD的总体患病率为10.1%,男性 (11.8%) 的患病率高于女性 (8.5%).
- 年龄是一个显著的风险因素,整体组合OR为1.94每10年增量.
- 吸烟包年在女性中与COPD有显著的关联 (合并OR=1.28) 但在男性中没有 (合并OR=1.16).
结论:
- 这项研究显示,COPD的患病率和病期比以前全球报告的更高,并且比以前报告的更晚.
- 虽然年龄和吸烟是主要因素,但它们不能完全解释COPD流行率的观察到的变化,这表明其他未确定的因素的重要性.
- 了解这些额外的因素对于在全球范围内制定有效的COPD初级和二级预防策略至关重要,尤其是在老龄化人口中.
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