利博胺技术专利利博胺技术专利

A R Goldberg

Science (New York, N.Y.)

|March 15, 1991

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Targeted cleavage of RNA molecules by human RNase P using minimized external guide sequences.

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Targeting the PML/RAR alpha translocation product triggers apoptosis in promyelocytic leukemia cells.

Short oligonucleotides as external guide sequences for site-specific cleavage of RNA molecules with human RNase P.

Delivery of oligoribonucleotides to human hepatoma cells using cationic lipid particles conjugated to ferric protoporphyrin IX (heme).

A ribozyme which discriminates in vitro between PML/RAR alpha, the t(15;17)-associated fusion RNA of acute promyelocytic leukemia, and PML and RAR alpha, the transcripts from the nonrearranged alleles.

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Targeted cleavage of RNA molecules by human RNase P using minimized external guide sequences.

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Targeted cleavage of RNA molecules by human RNase P using minimized external guide sequences.

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利博胺技术专利利博胺技术专利

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