人类乳头瘤病毒和子宫癌
Mark Schiffman1, Philip E Castle, Jose Jeronimo
1Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. schiffmm@mail.nih.gov
Lancet (London, England)
|September 11, 2007
概括
人类乳头瘤病毒 (HPV) 几乎导致所有宫癌. 了解HPV基因型及其在子宫癌进展中的作用,是制定全球有效的预防和查策略的关键.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 子宫癌是一个重要的全球健康问题,主要是由持续的人类乳头瘤病毒 (HPV) 感染引起的.
- 病变发生过程涉及从最初的感染到侵袭性癌症的多步骤过程.
研究的目的:
- 阐明HPV基因型在子宫癌发生中的作用.
- 突出一种以HPV为导向的模型对于理解和管理宫癌的重要性.
- 强调HPV相关技术在预防和控制方面的潜力.
主要方法:
- 审查和综合有关HPV感染和宫癌发展的当前知识.
- 对宫癌发生的多阶段进展模型的分析.
- 评估HPV基因型对癌症风险的影响.
主要成果:
- 特定致癌HPV基因型的持续感染是宫癌的主要原因.
- 宫癌的发展遵循一个明确的路径:感染,持久性,癌前期和入侵.
- 不同的HPV基因型表现出不同的致癌潜力.
结论:
- 对宫癌发生的HPV为中心的理解至关重要,应该取代旧的形态模型.
- 改进的查测试和针对HPV的疫苗提高了预防和管理.
- 与HPV相关的技术为全球范围内减少宫癌发病率,发病率和死亡率提供了一个有希望的策略,即使在资源有限的环境中也是如此.
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