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对AMP与哺乳动物AMP激活蛋白激酶结合的结构基础

Bing Xiao1, Richard Heath, Peter Saiu

  • 1MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

Nature
|September 14, 2007
PubMed
概括

AMP激活蛋白激酶 (AMPK) 调节细胞代谢. 它的结构揭示了AMP结合如何激活AMPK,通过调节能量平衡为II型糖尿病治疗提供了洞察力.

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