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大动脉扩张和剖析在特纳综合征
Lea Ann Matura1, Vincent B Ho, Douglas R Rosing
1Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Circulation
|September 19, 2007
概括
患有特纳综合征 (TS) 的女性患上大动脉剖析的风险增加. 大动脉尺寸指数>2.0厘米/平方米表明大动脉扩张显著,需要密切监测剖析风险.
科学领域:
- 心血管医学 心血管医学
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 特纳综合征 (TS) 与年轻女性大动脉剖析风险增加有关.
- 在TS中大动脉扩张和急性大动脉剖析之间的关系尚不清楚.
- 在TS患者中大动脉恶化的预测因素需要进一步调查.
研究的目的:
- 为了调查大动脉扩张是否在特纳综合征妇女的大动脉剖析之前.
- 为了确定特定的大动脉直径测量,预测TS.即将发生的大动脉事件.
- 评估大动脉大小指数在TS患者心血管风险管理中的有用性.
主要方法:
- 追溯分析了166名患有TS的成年女性和26名健康的女性对照.
- 通过MRI测量的上升和下降大动脉直径,正常化为身体表面积 (大动脉大小指数).
- 随访大约3年以记录大动脉剖析事件.
主要成果:
- 与对照组相比,TS患者的绝对大动脉直径相似,但大动脉大小指数显著增加.
- 32%的TS女性表现出大动脉尺寸指数值超过95百分位数 (>2.0厘米/米2).
- 三名TS女性经历了大动脉剖析,所有人的上升大动脉直径>3.7厘米和大动脉尺寸指数>2.5厘米/米2.
结论:
- 在TS的年轻女性中,大动脉解剖的风险显著增加.
- 大动脉尺寸指数是检测TS中扩张的首选措施,因为它们的身高较低.
- 大动脉尺寸指数>2.0厘米/平方米需要密切的心血管监测;>2.5厘米/平方米表明剖析的最高风险.
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