阿波利波蛋白E基因型与脂质水平和冠状动脉风险的关联
Anna M Bennet1, Emanuele Di Angelantonio, Zheng Ye
1Department of Public Health and Primary Care, University of Cambridge, Cambridge, England.
JAMA
|September 20, 2007
概括
阿波蛋白E (apoE) 基因型影响脂质水平和冠状动脉风险. 具有apoE epsilon2/epsilon2基因型的个体具有较低的LDL-C,而epsilon4载体则显示出略有增加的冠状动脉疾病风险.
科学领域:
- 遗传学和心血管疾病研究.
- 脂质代谢和心血管健康.
- 种群遗传学和疾病风险评估.
背景情况:
- 之前对阿波利波蛋白E (apoE) 基因型和冠状动脉疾病的审查受限于容易产生偏见的较小研究.
- 需要进行全面的重新评估,以澄清apoE基因型,脂质水平和冠状动脉风险之间的关联.
研究的目的:
- 进行更新的元分析,重新评估阿波利波蛋白E (apoE) 基因型与循环脂水平的关联.
- 评估apoE基因型与整体冠状动脉风险之间的关系.
主要方法:
- 进行了更新的元分析,结合了来自多个数据库 (MEDLINE,EMBASE,BIOSIS等) 的已发表和未发表的研究. 在1970年至2007年之间.
- 包括82项关于脂质水平的研究 (86,067名参与者) 和121项关于冠状动脉结局的研究 (37,850例,82,727例对照),优先考虑较大的研究.
- 基因型频率,脂质水平,冠状动脉结果和特征的数据由两个研究人员独立提取.
主要成果:
- 阿波脂蛋白E (apoE) 基因型与低密度脂蛋白胆固醇 (LDL-C) 和冠状动脉风险大致呈线性关系.
- 具有epsilon2/epsilon2基因型的个体与epsilon4/epsilon4载体相比,LDL-C显著降低.
- 与epsilon3/epsilon3基因型相比,apoE epsilon2载体的冠状动脉疾病几率比率降低 (0.80),而epsilon4载体的几率比率略高 (1.06).
结论:
- 阿波蛋白E (apoE) 基因型与LDL-C水平和冠状动脉疾病风险都呈现出大约线性关联.
- 携带apoE epsilon2等位基因的个体患冠心病的风险降低了20%,而epsilon4携带者与epsilon3/epsilon3个体相比风险略高.
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