热冲击因子1是一个强大的多面性修饰器的致癌
Chengkai Dai1, Luke Whitesell, Arlin B Rogers
1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Cell
|September 25, 2007
概括
热冲击因子1 (HSF1) 对癌症生长至关重要. 消除HSF1保护小鼠免受瘤的影响,并使人类癌细胞更依赖它生存.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 热冲击因子1 (HSF1) 是热冲击反应的保守调节器.
- 在各种病理生理条件下,HSF1提高了生存率.
- 在恶性瘤中HSF1的作用在很大程度上是未被探索的.
研究的目的:
- 研究HSF1在瘤发生过程中的作用.
- 确定HSF1是否有助于瘤开始和进展.
- 探索HSF1在恶性转变中的功能.
主要方法:
- 使用具有致癌突变 (RAS,p53) 的小鼠模型.
- 细胞培养实验评估了HSF1在转化中的作用.
- 在癌症和正常细胞中对HSF1依赖的比较分析.
主要成果:
- 从RAS和p53突变诱导的瘤中消除HSF1受保护的小鼠.
- HSF1通过调节增殖,生存,蛋白质合成和葡萄糖代谢来支持恶性转变.
- 不同的人类癌症系表现出比非转化细胞更大的HSF1依赖性.
结论:
- HSF1是致癌转变和癌症进展的关键促进者.
- 向HSF1可能提供针对各种癌症的治疗策略.
- HSF1在癌症中的作用与其在其他疾病中的保护功能形成鲜明对比.
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