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相关概念视频

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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相关实验视频

Updated: May 10, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

将树突细胞纳入医学领域

Ralph M Steinman1, Jacques Banchereau

  • 1The Rockefeller University, New York 10065, USA. steinma@mail.rockefeller.edu

Nature
|September 28, 2007
PubMed
概括

树突细胞 (DCs) 是主要的免疫调节体. 了解它们在疾病和免疫中的双重作用为开发针对性疫苗和治疗感染,癌症和自身免疫性疾病的治疗提供了新的途径.

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 疫苗学 疫苗学 疫苗学

背景情况:

  • 树突细胞 (DCs) 是免疫反应的关键协调者,影响自我耐受性和对病原体的抵抗力.
  • DCs在疾病中扮演着双重角色,要么促进不必要的免疫反应,要么被病原体和瘤利用来逃避免疫力.

研究的目的:

  • 探索树突细胞生物学在各种疾病中的医学含义.
  • 突出基于DC函数的预防和治疗机会.

主要方法:

  • 关于树突细胞生物学及其在疾病中的作用的现有文献的审查和综合.
  • 分析如何调节直流功能的治疗效益.

主要成果:

  • 可以利用DCs通过增强免疫反应来产生对感染和癌症的抵抗力.
  • 针对DC的疫苗显示出提高耐药性的潜力.
  • DCs可以在治疗上进行调节,以使过敏,自身免疫和移植排斥等不必要的免疫反应沉默.

结论:

  • 了解树突细胞生物学对于开发针对一系列疾病的新策略至关重要.
  • 向树突细胞为预防和治疗传染病,瘤和自身免疫疾病提供了显著的潜力.

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Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice
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Last Updated: May 10, 2026

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Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

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Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice
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Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Published on: July 1, 2022