由于占主导地位的,与性别相关的遗传,在鱼中迅速出现了抗菌病毒的耐药性
S Asser-Kaiser1, E Fritsch, K Undorf-Spahn
1Laboratory of Biotechnological Crop Protection, Department of Phytopathology, Agricultural Service Center Palatinate (DLR Rheinpfalz), Breitenweg 71, 67435 Neustadt an der Weinstrasse, Germany.
Science (New York, N.Y.)
|September 29, 2007
概括
用于害虫防治的昆虫特异性baculoviruses在蝶中显示出快速的耐药性. 这种超过1000倍的耐药性,需要对这些生物控制剂采取新的管理策略.
科学领域:
- 农业昆虫学 农业昆虫学
- 昆虫病理学 昆虫病理学
- 虫害管理 虫害管理 虫害管理
背景情况:
- 细菌病毒,特别是Cydia pomonella granulovirus (CpGV),是类害虫的重要生物控制剂.
- 以前的理解表明,昆虫百科病毒对害虫耐药性的发展具有抵抗力.
- 德国的实地观察显示,鱼种群对CpGV.有显著的耐药性.
研究的目的:
- 研究鱼 (Cydia pomonella) 对C. pomonella granulovirus (CpGV) 的现场耐药性的机制和程度.
- 了解导致虫害群体中CpGV耐药性的快速演变的遗传因素.
- 突出强调迫切需要在基于baculovirus的害虫防治中使用耐药性管理策略.
主要方法:
- 在德国果园中实地监测鱼种群,这些果园有记录的CpGV耐药性.
- 通过比较敏感和耐药菌株的生物测试来量化耐药性水平.
- 分析影响耐药性的遗传因素,包括基因链接和主导地位.
主要成果:
- 在超过1000倍的野外种群中观察到的抗性比率.
- 确定了主要耐药性基因的性别联系和度依赖的主导地位,作为关键促进因素.
- 证明抗性基因的固定可以导致抗性水平接近10万倍.
- 突出了病毒遗传统一性在抗药性传播的快速扩散中的作用.
结论:
- 鱼种群已经对CpGV产生了高水平的耐药性,这挑战了其作为生物控制剂的有效性.
- 遗传因素,包括性别联系和基因优势,加速了耐药性发展.
- 紧急开发和实施耐药性管理策略对于农业中可持续使用baculoviruses至关重要.
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