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通过H2A二基因化对细胞周期进展和基因表达的调节

Heui-Yun Joo¹, Ling Zhai, Chunying Yang

¹Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Kaul Human Genetics Building 402A, 720 South 20th Street, Birmingham, Alabama 35294, USA.

|October 5, 2007

概括

研究人员确定了Ubp-M (USP16) 作为从基因素H2A中去除乌比奎的关键酶. 这一过程对于细胞周期的进展,基因调节和适当的胚胎发育至关重要.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
分子生物学分子生物学
细胞生物学细胞生物学

背景情况:

翻译后的组织蛋白修饰调节了染色体的结构和功能.
基因组无处不在,特别是在H2A和H2B上,起着重要的作用.
负责H2A脱化酶的酶及其功能以前是未知的.

研究的目的:

为了识别和功能性地描述主要的双基因酶对 histone H2A.
阐明H2A二氧化在细胞过程和基因调节中的作用.

主要方法:

鉴定Ubp-M (USP16) 是主要的H2A二维基因酶.
在体外和体内测试以评估基质特异性和二维基因化活性.
细胞研究涉及HeLa细胞中Ubp-M的淘汰.
研究Ubp-M在Xenopus laevis发育中的作用.

主要成果:

Ubp-M 专门在核细胞基质上对基因组H2A,而不是H2B进行二基因化.
阻断Ubp-M导致细胞循环缺陷,特别是在线粒分裂过程中.
由Ubp-M进行的H2A二基化对于H3 Ser10酸化和染色体分离至关重要.
Ubp-M 调节 Hox 基因表达,对于 Xenopus 的后部发育至关重要.

结论:

鉴定Ubp-M (USP16) 是主要的组织素H2A二维基因酶.
H2A二维基因化是细胞周期进展和基因表达的关键过程.
这一发现提供了有关染色体和发育的调节机制的见解.

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