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Updated: Jul 11, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

一种化学方法,用于药物优化抗艾滋病毒蛋白

Les P Miranda1, Haiyan Shao, Jason Williams

  • 1Gryphon Therapeutics, 600 Gateway Boulevard, South San Francisco, California 94080, USA. lesm@amgen.com

Journal of the American Chemical Society
|October 6, 2007
PubMed
概括

化学合成的CCL-5蛋白衍生物 (RANTES) 显示出强大的抗HIV活性. 这种化学蛋白质合成方法显著提高了新型HIV治疗药物的药物配置文件.

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Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...