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质细胞通过在C. elegans中通过UNC-6 (网林) 信号传递促进局部突触生成

Daniel A Colón-Ramos¹, Milica A Margeta, Kang Shen

¹Department of Biological Sciences, Stanford University, 144 Herrin Laboratories, Stanford, CA 94305-5020, USA.

Science (New York, N.Y.)

|October 6, 2007

概括

质细胞指导C. elegans的神经电路组合. 它们通过指导神经元生长和通过网信号传递促进突触形成来协调连接,揭示了网在指导和突触发生过程中的双重作用.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
细胞生物学细胞生物学

背景情况:

神经电路的形成需要在前和后突触神经元之间进行精确的协调.
质细胞越来越多地被认为是指导神经元发育和电路组装中的角色.

研究的目的:

研究质细胞在调节C. elegans特定内神经元 (AIY和RIA) 之间的突触连接中的作用.
阐明基质导向神经电路组件背后的分子机制,重点关注网林信号传递.

主要方法:

在Caenorhabditis elegans中利用遗传分析.
研究了AIY和RIA内部神经元中网素 (UNC-6) 和其受体UNC-40 (DCC) 的功能.
研究了质细胞参与指导神经元过程生长和突触形成.

主要成果:

表达UNC-6 (尼特林) 的质细胞协调AIY-RIA内部神经元连接.
在后突触神经元RIA中,UNC-40 (DCC) 调解了向质细胞的腹腔过程外生,这是传统的指导作用.
在前突触神经元AIY中,UNC-40 (DCC) 意外地促进了细胞自主前突触终端组合在质末脚附近.

结论:

网氨酸信号在神经电路组合中起着双重作用:指导神经元过程并促进局部突触生成.
质细胞作为关键的指导柱,在体内促进神经元指导和突触形成.
这项研究揭示了UNC-40 (DCC) 在突触前发育中的新功能,并突出了质在神经系统连接中的多方面的作用.

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