阿波利波蛋白A-II与未来冠状动脉疾病的风险相反相关
Rakesh S Birjmohun1, Geesje M Dallinga-Thie, Jan Albert Kuivenhoven
1Academic Medical Center, Department of Vascular Medicine, 1100 DD, Amsterdam, The Netherlands.
Circulation
|October 10, 2007
概括
在健康人群中,阿波利波蛋白A-II (apoA-II) 与冠状动脉疾病 (CAD) 的风险降低有关. 较高的apoA-II水平与显著降低患CAD的风险有关.
科学领域:
- 心血管科学 心血管科学
- 脂质代谢 脂质代谢是什么
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 阿波利波蛋白A-I (apoA-I) 的血管保护作用已得到充分证实.
- 阿波利波蛋白A-II (apoA-II) 已引起争议,一些研究表明它具有益风性质.
研究的目的:
- 调查血清中apoA-II和apoA-I水平与未来冠状动脉疾病 (CAD) 风险之间的关联.
- 为了澄清apoA-II在动脉动脉生成中的作用.
主要方法:
- 在未来的EPIC-诺福克队列中进行了一项嵌套病例控制研究.
- 分析了912例 CAD 病例和1635个匹配的对照组 (45-79岁).
- 使用条件后勤回归来评估apoA-II水平与CAD风险之间的关系,并对各种心血管风险因素进行调整.
主要成果:
- 与对照组相比,CAD病例中的血清apoA-II度明显较低.
- ApoA-II与CAD风险相反相关;在完全调整 (OR 0.48) 后,最高四分位数的个体的风险降低了52%.
- 即使调整了apoA-I水平和HDL颗粒特征,这种关联仍然显著.
结论:
- 在看似健康的个体中,ApoA-II与未来CAD的风险降低有关.
- 这些发现表明,apoA-II可能会产生直接的抗风险效应.
- ApoA-II的潜在益动脉起作用需要重新评估.
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