微角中子和X射线散射来自对形刺激有反应的钻石型双连续立方相
Borislav Angelov1, Angelina Angelova, Vasil M Garamus
1Institute of Biophysics, Bulgarian Academy of Sciences, BG-1113 Sofia, Bulgaria.
Journal of the American Chemical Society
|October 13, 2007
概括
脂质立方相与水合剂剧烈膨胀,形成具有可调节纳米通道的大型结构. 这种可逆转变使得纳米载体的控制释放成为可能.
科学领域:
- 软物质科学 软物质科学
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 脂质立方相表现出复杂的结构,具有药物输送潜力.
- 了解它们对刺激的结构反应对于开发先进的纳米载体至关重要.
研究的目的:
- 在热和化学刺激下研究钻石型双连续脂质立方相的结构演变.
- 探索这些相作为刺激响应纳米载体的潜力.
主要方法:
- 采用了小角度中子散射 (SANS) 和小角度X射线散射 (SAXS).
- 在应用水化剂 (octyl glucoside) 和温度变化时,监测结构变化.
主要成果:
- 随着水化,观察到剧烈的胀 (DLarge立方结构),使水道直径翻倍至7nm.
- DLarge阶段包括立方体和状域,转化为体温以上的DNormal阶段.
- 可逆结构转变 (DLarge-DNormal) 通过受控的水合和温度变化来实现.
结论:
- 刺激响应性脂质立方相提供可调的纳米通道水化和可逆结构转换.
- 这提供了一个基于结构的策略,用于从立方体纳米载体控制释放.
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